Regulation of Hemoglobin Synthesis during the Development of the Red Cell

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Abstract
(First of Three Parts)The process of erythroid-cell differentiation represents one of the most striking examples of biologic specialization known in nature. Erythropoiesis begins with an undifferentiated stem cell that, within seven to 10 days, gives rise to mature erythrocytes containing only the subcellular components adapting them to long-term survival and oxygen transport in the circulation. A remarkable accumulation of hemoglobin is achieved in the circulating erythrocyte. Indeed, in terminally differentiated late erythroblasts and reticulocytes, over 95 per cent of the total protein synthesis is devoted to the accumulation of the globin subunits of hemoglobin. Yet the structural genes coding . . .