IgA class antibodies against Yersinia enterocolitica O:3 in patients with thyroid disease
- 1 September 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 119 (1) , 81-84
- https://doi.org/10.1530/acta.0.1190081
Abstract
IgM, IgG and IgA class serum antibodies against Y. enterocolitica O:3 and O:9 and Y. pseudotuberculosis 1a and 3 in 41 patients with thyroid disease and 50 healthy control persons were measured by enzyme-linked immunosorbent assay (ELISA). Concentrations of antibody levels against Y. enterocolitica O:9 and Y. pseudotuberculosis 1Q and 3 did not differ significantly between the patients and controls. The median value of IgA class antibody Y. enterocolitica O:3 was 7.5 relative units (EIU, percentage of the reference serum) in the patients with thyroid disease and 0.7 EIU in the controls (P < 0.01; Mann-Whitney''s U-test), whereas IgM and IgG class antibodies did not show this difference. IgA class serum antibodies were especially high in patients with autoimmune thyroid diseases. These findings and two case reports support the concept that there may be a causal relationship between infections with Y. enterocolitica O:3 and autoimmune thyroid diseases.This publication has 6 references indexed in Scilit:
- THYROTROPIN (TSH) BINDING-SITES ON YERSINIA-ENTEROCOLITICA RECOGNIZED BY IMMUNOGLOBULINS FROM HUMANS WITH GRAVES-DISEASE1986
- Demonstration of a Saturable Binding Site for Thyrotropin in Yersinia enterocoliticaScience, 1983
- Persistence of IgM, IgG, and IgA Antibodies to Yersinia in Yersinia ArthritisThe Journal of Infectious Diseases, 1980
- Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during diseaseJournal of Clinical Microbiology, 1979
- Antibodies to Yersinia enterocolitica in Thyroid DiseaseAnnals of Internal Medicine, 1976
- INDIRECT IMMUNOFLUORESCENCE STAINING OF HUMAN THYROID BY ANTIBODIES OCCURRING IN YERSINIA-ENTEROCOLITICA INFECTIONS1976