Familial Neuroblastoma

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Abstract
A diagnosis of neuroblastoma was made in two siblings, each at 5½ months of age. Both siblings are living and well, 2½ years and nine months, respectively, after surgery and x-ray therapy. The father had increased levels of 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid [VMA]) in his urine, but there was no clinical evidence of a neural tumor. The results of studies in this family suggest that neuroblastoma may be inherited in an autosomal dominant pattern after mutation of the genes governing the neural crest formation.