TRANSFERABLE TETRACYCLINE RESISTANCE IN CLOSTRIDIUM-DIFFICILE

  • 1 January 1980
    • journal article
    • research article
    • Vol. A131  (2) , 171-179
Abstract
Tetracycline (Tc) resistance is transferable from a resistant strain of C. difficile to a sensitive strain and this resistance is not curable. Resistances to erythromycin and clindamycin are curable but not transferable. These results suggest that these resistances are plasmid determined. A plasmid-mediated Tc resistance (pIP401) of C. perfringens is also transferable to C. difficile. Tc resistance is inducible in C. perfringens and constitutively expressed in C. difficile. In the Tc-resistant transcipients of C. difficile, this resistance is either inducible or constitutive, whether the Tc-resistant donor strain was C. perfringens or C. difficile.

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