A linkage group with FRA16B (the fragile site at 16q22.1)
- 1 May 1989
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 82 (2) , 131-133
- https://doi.org/10.1007/bf00284044
Abstract
Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants \({\text{(}}\hat \theta = {\text{0}}{\text{.0, }}{\mathbf{\hat z}}{\text{ = 8}}{\text{.3)}}\) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.
This publication has 21 references indexed in Scilit:
- Restriction fragment length polymorphisms detected by anonymous DNA probes mapped to defined intervals of human chromosome 16Human Genetics, 1988
- Fine mapping of gene probes and anonymous DNA fragments to the long arm of chromosome 16Genomics, 1988
- A genetic linkage map of the human genomeCell, 1987
- Molecular genetics of human chromosome 16.Journal of Medical Genetics, 1987
- Report of the committee on the genetic constitution of the X and Y chromosomesCytogenetic and Genome Research, 1987
- The fragile site (16) (q22)Human Genetics, 1986
- Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridizationCytogenetic and Genome Research, 1986
- Report of the Committee on Human Gene Mapping by Recombinant DNA Techniques (Part 1 of 5)Cytogenetic and Genome Research, 1985
- Serum cholinesterase (E2) linkage analysis: possible evidence for localization to chromosome 16Cytogenetic and Genome Research, 1978
- Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in ManScience, 1970