Antiarrhythmic peptide has no direct cardiac actions

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Abstract
The electrophysiologic, inotropic, and muscarinic effects of antiarrhythmic, peptide (AAP) were examined in canine cardiac Purkinje fibers, ferret papillary muscle, and canine cardiac membranes, respectively. Aside from a prolongation of time to peak force, in papillary muscle, no biologically significant effects of AAP could be determined in any, preparation, suggesting that its antiarrhythmic, effects are not mediated by direct membrane actions.