Development of Acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum

1 November 2001

journal article
case report
Published by Wolters Kluwer Health in The Pediatric Infectious Disease Journal

Vol. 20 (11) , 1094-1097
https://doi.org/10.1097/00006454-200111000-00021

Abstract

Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.

Keywords

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