EXPERIMENTAL STUDIES ON THE CARBONIC ANHYDRASE ACTIVITY IX. THE MODE OF ACTION OF ADRENOCORTICAL STEROIDS, ESPECIALLY ALDOSTERONE, ON THE CARBONIC ANHYDRASE IN MICE AND RATS

Publisher Website
Google Scholar
Abstract
The action of aldosterone on renal carbonic anhydrase activity of normal or adrenalectomized mice and rats is opposite in the 2 animals, being accelerative in the former and inhibitory in the latter. The effect of adrenalectomy on the renal enzymic activity is inhibitory in the former species and accelerative in the latter. This is an example of a difference in hormonal action between animal species. Presumably there is a species difference in the synthesis of renal carbonic anhydrase after aldosterone treatment. This difference may be dependent on the amount of other synthesized enzymes participating in Na metabolism, for example, ATP ase. In mice the increase in carbonic anhydrase synthesis affected by aldosterone may cause the decrease in ATPase synthesis. The situation is reversed in rats. All preceding experiments were reviewed and the mechanism of aldosterone action on the kidney was discussed.