Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement
- 25 June 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3990) , 1355-1357
- https://doi.org/10.1126/science.172.3990.1355
Abstract
In mice the activation caused by morphine was antagonized by previous treatment with lithium and was potentiated by previous treatment with rubidium. Other antimanic drugs antagonized the morphine activation as well. The effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline. Rubidium may merit clinical evaluation as an antidepressant agent in man.Keywords
This publication has 19 references indexed in Scilit:
- Lithium Prophylaxis in Recurrent Affective DisordersThe British Journal of Psychiatry, 1970
- Brain Norepinephrine: Enhanced Turnover after Rubidium TreatmentScience, 1970
- Possible Mechanism of Action of Morphine on BrainNature, 1970
- Effects of tricyclic antidepressants on the uptake and metabolism of intracisternally administered norepinephrine-H3 in rat brainJournal of Psychiatric Research, 1969
- Rubidium: a Potential Modifier of Affect and BehaviourNature, 1969
- Effects of morphine intoxication on brain catecholamine neuronsEuropean Journal of Pharmacology, 1969
- Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-HydroxytryptamineScience, 1968
- Evoked Release of Norepinephrine and Serotonin from Brain Slices: Inhibition by LithiumScience, 1968
- The effects of lithium ion on H3 -norepinephrine metabolism in brainLife Sciences, 1966
- THE ACCUMULATION OF EXCESS SALT BY SOLUTIONS OF STRANDIN*Journal of Neurochemistry, 1966