Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 284 (5753) , 238-243
- https://doi.org/10.1038/284238a0
Abstract
A mouse cloned c[complementary]DNA probe containing a variable (V) region belonging to the VHIII subgroup was used in filter hybridizations to estimate the number of H chain V-genes in this subgroup of mouse and human DNA. There seem to be about 10 and 20 VH-genes hybridizing to this probe in mouse and human DNA, respectively. Studies of cross-hybridization of the related V.kappa.-genes from MOPC-21 and MPC-11 myelomas indicate that the experiments detect all members of the VHIII subgroup.This publication has 28 references indexed in Scilit:
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