Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
- 1 January 1982
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 322 (1) , 447-455
- https://doi.org/10.1113/jphysiol.1982.sp014048
Abstract
To test the hypothesis that brain protein synthesis is necessary for fever, 3 structurally similar trichothecene antibiotics were injected into the cerebral ventricles of rabbits. They were 3,15-diacetoxy-12-hydroxytrichothec-9-ene (DAHT), 3,15-dideacetyl-calonectrin (DDAC) and T-2 toxin. Their actions on hypothalamic incorporation of [14C]leucine and fever were compared. DDAC (60 .mu.g) and T-2 toxin (10 .mu.g) strongly inhibited leucine incorporation and fever. DAHT (60 .mu.g) did not diminish fever and had a smaller effect upon leucine incorporation. The findings strengthen considerably earlier suggestions that brain protein synthesis is an essential step in pyrogenesis.This publication has 24 references indexed in Scilit:
- THE EFFECTS OF INTRACEREBROVENTRICULAR CYCLOHEXIMIDE ON PROTEIN SYNTHESIS AND FEVER IN RABBITSBritish Journal of Pharmacology, 1981
- The role of protein synthesis in the hypothalamic mechanism mediating pyrogen feverBrain Research Bulletin, 1980
- Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.The Journal of Physiology, 1977
- Evidence that brain prostaglandin synthesis is not essential in fever.The Journal of Physiology, 1976
- Inhibition at the initiation level of eukaryotic protein synthesis by T‐2 toxinFEBS Letters, 1975
- The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- THE PREVENTION BY INHIBITORS OF BRAIN PROTEIN SYNTHESIS OF THE HYPERACTIVITY AND HYPERPYREXIA PRODUCED IN RATS BY MONOAMINE OXIDASE INHIBITION AND THE ADMINISTRATION OF L‐TRYPTOPHAN OR 5‐METHOXY‐N,N‐DIMETHYLTRYPTAMINEJournal of Neurochemistry, 1972
- Molecular weight, buoyant density, and composition of active subunits of rat liver ribosomesBiochemistry, 1971
- The mechanism of cycloheximide inhibition of protein synthesis in rabbit reticulocytesBiochemical and Biophysical Research Communications, 1969
- Chloramphenicol inhibition of the formation of particulate mitochondrial enzymes of Saccharomyces cerevisiaeBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966