SUPPRESSION OF NEPHROTOXIC SERUM NEPHRITIS IN RATS BY PROSTAGLANDIN-E1

  • 1 January 1982
    • journal article
    • research article
    • Vol. 108  (2) , 240-245
Abstract
The ability of specific prostaglandins to modulate the development of nephrotoxic serum nephritis (NSN) in rats was examined. The nephrotoxicity of 1 i.v. injection of antibodies directed against rat glomerular basement membrane (GBM) was markedly suppressed by treatment with a stable analog of prostaglandin E1 (15-(S)-15-methyl PGE1; 15-M-PGE1). Prostaglandin E1 treatment suppressed both glomerular hypercellularity and proteinuria, while the binding of specific antibody to the GBM was not altered. Certain prostaglandins may play an important role in the regulation of Type II immune reactions. Investigations of the role of arachidonic acid products undoubtedly will provide valuable information regarding the modulation of tissue injury as a result of various inflammatory reactions.