NICOTINAMIDE STIMULATES THE REPAIR OF CARCINOGEN-INDUCED DNA DAMAGE IN THE HAMSTER PANCREAS INVIVO
- 1 January 1983
- journal article
- research article
- Vol. 3 (3) , 207-210
Abstract
A single dose of nicotinamide (350 mg/kg, i.p.) given 3 h after a single dose of the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg, s.c.) stimulated the repair of DNA damage induced by BOP in the hamster pancreas. Damage was measured by alkaline elution 24 h after dosing with BOP. When given up to 1 h before BOP nicotinamide was ineffective. This effect did not appear to be due to an alteration in the rate of unscheduled DNA synthesis which was not stimulated by nicotinamide. These data correlated positively with the inhibitory action of nicotinamide on BOP carcinogenesis in the hamster pancreas.This publication has 7 references indexed in Scilit:
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