STUDIES ON PASSIVE IMMUNITY IN POLIOMYELITIS

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Abstract
Thirty rhesus monkeys have been repeatedly injected with Lansing polio-myelitis virus by the intramuscular route. Antibody, as measured by a virus-neutralization test in mice, rapidly developed in the serum. About 3 liters of immune serum with a 50% neutralizing titer of 10−3.0 or higher were collected with a view to fractionation. Antibody levels tended to be maintained during rest periods when no injections were given. The evidence suggests that, on the whole, antibody levels were higher in animals receiving virus incorporated in paraffin oil adjuvant than in those receiving virus suspended in water. Certain individual monkeys receiving virus in water responded as well, however, as monkeys receiving virus in adjuvant.