NORMAL CONCENTRATIONS OF SOME TRACE METALS IN HUMAN URINE: CHANGES PRODUCED BY ETHYLENEDIAMINETETRAACETATE *

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Abstract
A spectro-graphic method is described for simultaneously determining the concentrations of transition and related trace metals in human urine. The mean urinary concentrations of Zn, Cd, Mn, Pb, V, Mo, Ni, Ag, Sn, and their standard errors were determined for 24 normal adults. Day-today variations in the renal excretion of these metals and the changes occurring in acidic, basic, dilute, and concentrated urine were measured for one normal adult. Hospitalized African Negroes from Ruanda Urundi had suggestively more urinary Ni than did healthy Americans. Marked increases in urinary Zn and lesser increases in urinary Cd, Mn, Pb, and V were observed during the administration of disodium calcium ethylenediaminetetraacetate to 8 hypercholesterolemic patients.