Peripheral vascular response to phenoxybenzamine infusion in isolated dog hindlimb

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Abstract
Measurements of changes in peripheral venous pressure in digital and muscle veins, arterial pressure, leg weight, and venous outflow were made under conditions of constant arterial inflow during phenoxybenzamine infusion into the isolated dog hindlimb. It is shown that intra-arterial infusion of phenoxybenzamine (2.0-4.0 mg/kg per min) results in arteriolar dilatation, peripheral digital vein constriction, and decreases in peripheral muscle venous pressure. Evidence is given to show that one factor in the mechanism of this response is the release of histamine from its tissue storage place. These studies support the previously published data of Haddy that histamine will constrict small veins while simultaneously lowering arterial pressure, and that this may be the mechanism for histamine-produced edema.