Long term increase of mucosal mast cells in the rat induced by administration of Compound 48/80

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Abstract
Administration of Compound 48/80 to rats for 5 days resulted in an increase of the specific type of mucosal mast cell; connective tissue mast cells elsewhere were almost completely degranulated. The number of mucosal mast cells increased slowly for another 5 days and then returned to the control level in an exponential manner. The half-life of the newly formed mast cells was calculated to be about 40 days. This value may be taken as an estimate of the half-life of mucosal mast cells. These cells constitute a fraction of mast cells with rapid turnover. Apparently the classical connective tissue mast cell has a very long life span, without significant turnover in terms of cell death and cell renewal. Apparently the increase of mucosal mast cells is an indirect effect of Compound 48/80, related to its effect on other mast cells and mediated by material(s) released from these cells during the secretory process.

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