A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.
Open Access
- 15 August 1998
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 102 (4) , 704-709
- https://doi.org/10.1172/jci2512
Abstract
In the first reported positive result from a genome scan for non-insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of lambdas (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score /= 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.Keywords
This publication has 27 references indexed in Scilit:
- Mapping Genes for NIDDM: Design of the Finland—United States Investigation of NIDDM Genetics (FUSION) StudyDiabetes Care, 1998
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- Genetic Analysis of NIDDM: The Study of Quantitative TraitsDiabetes, 1996
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995
- Asymptotic properties of affected-sib-pair linkage analysis.1993
- Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in FinlandDiabetologia, 1992
- Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in the Middle-Aged Population of Three Areas in FinlandInternational Journal of Epidemiology, 1991
- Construction of multilocus genetic linkage maps in humans.Proceedings of the National Academy of Sciences, 1987
- A simple method to detect linkage for rare recessive diseases: An application to juvenile diabetesClinical Genetics, 1979
- DOSE-RESPONSE RELATION BETWEEN PLASMA-INSULIN AND BLOOD-GLUCOSE LEVELS DURING ORAL GLUCOSE LOADS IN PREDIABETIC AND DIABETIC SUBJECTSThe Lancet, 1973