Cytoskeletal Requirements for Hepatitis C Virus (HCV) RNA Synthesis in the HCV Replicon Cell Culture System
Open Access
- 1 April 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (7) , 4401-4408
- https://doi.org/10.1128/jvi.77.7.4401-4408.2003
Abstract
Hepatitis C virus (HCV) induces microtubule aggregates in infected hepatocytes. To determine if cytoskeletal elements are important for HCV RNA synthesis, we examined the effect of cytoskeleton inhibitors on HCV replicon transcription in Huh7 cells. The data demonstrate that HCV replication complex-mediated RNA synthesis requires microtubule and actin polymerization.Keywords
This publication has 41 references indexed in Scilit:
- Efficient Initiation of HCV RNA Replication in Cell CultureScience, 2000
- Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell LineScience, 1999
- Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites.Molecular Biology of the Cell, 1996
- Intracytoplasmic Crystalline Inclusions in the Hepatocytes of Humans and ChimpanzeesUltrastructural Pathology, 1990
- Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis GenomeScience, 1989
- Involvement of microtubules in Kunjin virus replicationArchiv für die gesamte Virusforschung, 1987
- Beta-Propiolactone for the Inactivation of Non-A/Non-B Type 1 Hepatitis Virus Capable of Inducing Cytoplasmic Tubular Ultrastructures in ChimpanzeesVox Sanguinis, 1984
- Immunofluorescent sites in vero cells infected with the flavivirus KunjinArchiv für die gesamte Virusforschung, 1983
- Experimental non‐A, non‐B hepatitis in chimpanzees: Light, electron and immune microscopical observationsLiver International, 1983
- Microtubular aggregates in human chronic non‐A, non‐B hepatitis with bridging hepatic necrosis and multinucleated hepatocytic giant cellsLiver International, 1982