Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by alkaloids. II.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (11) , 4588-4592
- https://doi.org/10.1248/cpb.36.4588
Abstract
The structure-inhibitory activity relationships were studied in analogous alkaloids from Picrasma quassioides and Ailanthus altissima, and their derivatives. Altogether, 53 .beta.-carboline, 18 canthinone and 7 dimeric alkaloids were tested for cyclic adenosine monophospahte (cAMP) phosphodiesterase inhibition. Major alkaloids (10.63 and 74) among the three groups of congeners in Picrasma quassioides and Ailanthus altissima showed the most potent inhibitory activity, equal to or greater than that of papaverine used as a reference.This publication has 2 references indexed in Scilit:
- Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by lignan glucosides of Eucommia bark.CHEMICAL & PHARMACEUTICAL BULLETIN, 1988
- Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related .BETA.-carboline alkaloids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984