Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by lignan glucosides of Eucommia bark.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (1) , 435-439
- https://doi.org/10.1248/cpb.36.435
Abstract
Studies were conducted on adenosine 3'',5''-cyclic monophosphate (cyclic AMP) phosphodiesterase inhibition by lignan glucosides from bark of Eucommia ulmoides OLIV. (Eucommiaceae). Various lignan diglucosides, (+)-syringaresinol di-O-.beta.-D-glucopyranoside (1c). (+)-medioresinol di-O-.beta.-D-glucopyranoside (2c), (+)-pinoresinol di-O-.beta.-D-glucopyranoside (3c) and (+)-1-hydroxypinoresinol 4'',4''''-di-O-.beta.-D-glucopyranoside (4d), showed strong inhibitory activity. The structure inhibitory activity relationships of the aglycone and its glucosides are discussed. The order of inhibitory effect was diglucoside .gtoreq. aglycone > monoglucoside.This publication has 11 references indexed in Scilit:
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