Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by components of Sophora flavescens Aiton.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (5) , 2094-2099
- https://doi.org/10.1248/cpb.34.2094
Abstract
Adenosine 3'',5''-cyclic monophosphate (cAMP) phosphodiesterase inhibitors containing in the roots of Sophora flavescens Aiton were identified as flavonoids, kushenol A (9), kurarinone (5), and kuraridin (22). The structure-inhibitory activity relationships were studied in 30 flavonoids. O-Methylation of a hydroxyl group on an aromatic ring decreased the activity. The prenyl group is important for high inhibitory activity. A kinetic study revealed that non-kurarinone, kurarinol and kuraridin non-competitively inhibit cAMP phosphodiesterase.This publication has 6 references indexed in Scilit:
- Inhibitors of cyclic AMP phosphodiesterase in Panax ginseng C.A. Meyer and Panax japonicus C.A. Meyer.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related .BETA.-carboline alkaloids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Inhibitors of cyclic adenosine 3',5'-monophosphate phosphodiesterase in Phyllostachys nigra MUNRO var. henonis STAPF. and Phragmites communis TRIN., and inhibition by related compounds.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Inhibition of Cyclic AMP Phosphodiesterase by FlavonoidsPlanta Medica, 1982
- Inhibitors of cyclic adenosine monophosphate phosphodiesterase in Polygala tenuifolia.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982
- Inhibition of cyclic AMP phosphodiesterase by lignans.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981