Hypersensitivity of scleroderma cutaneous vascular smooth muscle to 5-hydroxytryptamine
- 1 July 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 95 (1) , 51-56
- https://doi.org/10.1111/j.1365-2133.1976.tb15534.x
Abstract
Vascular smooth muscle strips from subcutaneous wrist vessels of patients with scleroderma (systemic sclerosis) were studied in an isolated system. No difference between catecholamine response of scleroderma or control vessel strips was observed. Of 4 patients, 3 demonstrated significant hypersensitivity to 5-hydroxytryptamine as compared to control values. Serotonin hypersensitivity may play a role in the evolution of Raynaud''s phenomenon and vascular scleroderma.This publication has 18 references indexed in Scilit:
- 5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: A clinical pharmacological approach with p-chlorophenylalaninePsychopharmacology, 1973
- In Vitro Effects of Prostaglandin E2 on Cutaneous Vascular Smooth Muscle in the Dog And in ManJournal of Investigative Dermatology, 1973
- Contraction of Isolated Human Breast Cutaneous Vascular Smooth MuscleJournal of Investigative Dermatology, 1973
- Scleroderma-like Lesions and the Carcinoid SyndromeArchives of internal medicine (1960), 1973
- Humoral Responses of Smooth Muscle from Rabbit Subarachnoid Artery Compared to Kidney, Mesentery, Lung, Heart, and Skin Vascular Smooth MuscleStroke, 1972
- Skin capillary blood flow in sclerodermaJournal of Clinical Investigation, 1971
- Effect of Nicotinate Ester, Acetylcholine, and Other Vasodilating Agents on Cutaneous and Mesenteric Vascular Smooth MuscleCirculation Research, 1969
- Direct Tension Recording From Smooth Muscle of Resistance Vessels From Various OrgansAngiology, 1961
- Raynaud's Disease, Raynaud's Phenomenon, and SerotoninAngiology, 1960
- Response To Serotonin and Its Antagonists in Patients With Rheumatoid Arthritis and Related Diseases*†Angiology, 1959