RNA splicing generates a variant light chain from an aberrantly rearranged κ gene
- 31 July 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 286 (5775) , 776-779
- https://doi.org/10.1038/286776a0
Abstract
Both Cκ regions in MPC 11 cells are rearranged into active transcription units, one producing a normal κ chain and the other an internally deleted κ fragment lacking a V region. The gene coding for the κ fragment mRNA is aberrantly rearranged and lacks a site for V → Cκ splicing. An alternative splicing event which deletes the V region from the nuclear RNA precursor generates the κ fragment mRNA.Keywords
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