A genetic factor controlling morphogenesis of the laryngotracheo-esophageal complex in the mouse

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Abstract
A new autosomal, recessive lethal mutation in the mouse causes failure of division of the embryonic foregut into totally separate digestive and respiratory ducts. The newborn homozygote has a cleft that extends between the laryngotracheal and esophageal tubes, allowing excessive air to pass into the stomach and subsequently into the peritoneal cavity. This mutation has been designated lec (laryngotracheo‐esophageal cleft). The common region shared by the respiratory and digestive tubes has features characteristic of both structures. Development of cartilage around the laryngotracheo‐esophageal complex is also affected in the mutant.