Fibrinoid Vascular Changes Showing the Same Morphologic Pattern Following Induction by Various Experimental Conditions

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Abstract
The fibrinoid necrosis of the small blood vessels occurs in reaction to exposure of the vascular wall to a noxious agent. The histologic structure of the necrosis is closely correlated with the intensity of the noxa and the duration of exposure. Necrosis of the vascular wall develops in distinct phases which may not be very marked. Their development in time may depend only on the intensity of etiologic factors. The histologic pattern can suggest the intensity of the noxious effects to which the vessel was exposed. The results place the analysis of the fibrinoid necrosis of the human vascular wall in a different light.