Controlled perfusion pressure and vascular volume changes in dog forelimbs

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Abstract
In isolated dog forelimb preparations, perfusion pressure was increased from 75 to 200 mm Hg in steps of 25 mm Hg. Changes in blood flow, peripheral resistance, limb weight, 86RbCl recovery were determined. Vascular volume was estimated by red cells-51cr and albumin-131I. The peripheral resistance declined with each elevation of perfusion pressure until it reached 150 mm Hg. The resistance then stabilized as the perfusion pressure was increased to 175 and 200 mm Hg. Limb weight (fast change) and vascular volume increased together to the 150 mm Hg pressure level. Then the volumes determined from the indicators plateaued and the volume change from the weighing device continued to increase through the 175 and 200 mm Hg levels. 86RbCl re-covery increased with each pressure increment to the 150 mm Hg level and then remained constant for the remaining perfusion pressure increases. The venous time-concentration curves after intraarterial slug injections of albumin-131I had uniform downslopes through the 125 mm Hg pressure level, but a 2nd concentration peak appeared on the downslope of the succeeding curves. These data seem to indicate the opening of a 2nd circulation, not capillary in nature, when the perfusion pressure was above 125 mm Hg.

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