Antigenicity of Hyaluronic Acid.

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Abstract
Antigens were prepared from human umbilical cord and streptococcal hyaluronic acid, group A hemolytic streptococci, Staphylococcus aureus and these same bacteria incubated with human umbilical cord hyaluronic acid. Rabbits were inoculated intravenously, intramuscularly and sub-cutaneously. Neither precipitating nor non-precipitating, skin-sensitizing antibodies against hyaluronic acid developed. The development of skin sensitivity to streptococcal hyaluronic acid and crude umbilical cord extract was suggested but by no means proved. Hyaluronic acid is probably not antigenic by itself, nor does it act as a haptene capable of absorption to group A hemolytic streptococci or S. aureus.