The sensitizing capacity of coumarins (I)
- 1 August 1986
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 15 (3) , 157-163
- https://doi.org/10.1111/j.1600-0536.1986.tb01317.x
Abstract
10 Coumarins used in perfumery, cosmetics and ointments, have been investigated by2 different methods to determine their sensitizing capacity. Only 1 of the compounds, 4-methyl-esculetin, which serves as a sunscreen agent, was found to be a weak sensitizer. All otyer coumarins were negative. It is assumed that this dihydroxycoumarin becomes a sensitizer when it is enzymically oxidized to the corresponding orthoquinone in the skin.Keywords
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