External detection of pulmonary accumulation of indium-113m labelled transferrin in the guinea pig.
- 1 September 1990
- Vol. 45 (9) , 688-693
- https://doi.org/10.1136/thx.45.9.688
Abstract
Accumulation of radioisotope labelled tranferrin in the lungs of guinea pigs was determined with an external detection system. The method is based on the intravascular and extravascualr distribution of indium-113m labelled transferrin compared with the intravascular distribution of technetium-99m labelled red blood cells. Guinea pigs were given iloprost, a prostacyclin analogue and potent pulmonary vasodilator, and noradrenaline, a pulmonary vasoconstrictor, in an attempt to increase and decrease respectively the blood volume in the lungs. Neither agent altered transferrin accumulation in the lung by comparison with a saline infusion. Iloprost infused before and after oleic acid infusion reduced macromolecular leakage when compared with oleic acid alone. These data suggest that the double isotope method can distinguish between hydrostatic and injury induced pulmonary oedema.Keywords
This publication has 33 references indexed in Scilit:
- External113Inm and99Tcm radiation detection of lung edema induced by oleic acid in the guinea pigZeitschrift für Die Gesamte Experimentelle Medizin, 1988
- Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical.Journal of Clinical Investigation, 1987
- Pulmonary vascular permeability to transferrin in the pulmonary oedema of renal failure.Thorax, 1987
- Albumin lung/heart ratio change. A simple clinical means of documenting increased pulmonary endothelial permeability to proteinJAMA, 1987
- A noninvasive technique for monitoring lung vascular permeability in manNuclear Medicine Communications, 1985
- A modified technique for permeability studies in the superfused hamster cheek pouchLife Sciences, 1984
- The effect of prostacyclin on increased hydraulic conductivity of pulmonary exchange vessels following microembolization in dogsMicrovascular Research, 1983
- Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophilsBiochemical and Biophysical Research Communications, 1983
- Comparative scintigraphy in oleic acid pulmonary microvascular injuryCritical Care Medicine, 1982
- Sensitivity of Scintigraphy for Detection of Pulmonary Capillary Albumin Leak in Canine Oleic Acid ARDSPublished by Wolters Kluwer Health ,1981