Sensitivity of Scintigraphy for Detection of Pulmonary Capillary Albumin Leak in Canine Oleic Acid ARDS

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Abstract
Computerized gamma scintigraphy was shown in this study to bc a sensitive technique for the detection and kinetic analysis of a pulmonary capillary protein leak. A rising lung:heart radioactivity ratio or ‘slope of injury’ was found at each dose of intravenous oleic acid in dogs from 0.01 to 0.20 ml/kg (p < 0.01). This ‘slope of injury’ was proportional to the dose of oleic acid (r = +0.97; p < 0.004) and was more sensitive than changes in arterial oxygen tension, standard chest radiography, bloodless wet:dry lung weight, or alveolar epithelial membrane permeability. Only standard light microscopy and right lymphatic duet flow were able to document the leakage of protein detected by gamma scintigraphy at 0.01 ml/kg oleic acid.