Metabolism of amines. 3. The degradation and synthesis of γ-aminobutyric acid by Pseudomonas aeruginosa

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Abstract
Extracts of P. aeruginosa metabolized gamma-aminobutyric acid by transmination in the presence of a -oxoglutarate, pyruvate, oxaloacetate or a -oxovalerate. Succinic semialdehyde, produced by transamination, was further oxidized by tri- or di-phos-phopyridine nucleotide. Succinate was converted into succinic semi-aldehyde by reduced tri- or di-phosphopyridine nucleotide and yielded gamma-aminobutyric acid by transamination. The formation of 4-aminobutan-1-ol by the reductive animation of succinate, and the formation of gamma-amino[C14]butyric acid from [C14]succinate, are described.