Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth
- 18 August 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 313 (5789) , 971-975
- https://doi.org/10.1126/science.1121908
Abstract
Mutations in gld-1 cause lethal germline tumors in the nematode Caenorhabditis elegans . We find that a wide variety of mutations that extend C. elegans ' life span confer resistance to these tumors. The long life spans of daf-2/ insulin-receptor mutants were not shortened at all by gld-1 mutations; we attribute this finding to decreased cell division and increased DAF-16/p53–dependent apoptosis within the tumors. Mutations that increase life span by restricting food intake or inhibiting respiration did not affect apoptosis but reduced tumor cell division. Unexpectedly, none of these longevity mutations affected mitosis in normal germlines; this finding suggests that cellular changes that lead to longevity preferentially antagonize tumor cell growth.Keywords
This publication has 28 references indexed in Scilit:
- The Plasticity of Aging: Insights from Long-Lived MutantsCell, 2005
- Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cellsOncogene, 2005
- Dysregulation of the TSC-mTOR pathway in human diseaseNature Genetics, 2004
- Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiationNature Genetics, 2004
- Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegansNature, 2003
- Genetics and the Specificity of the Aging ProcessScience, 2003
- The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosisCurrent Biology, 2001
- Alteration of Cell Cycle-dependent Histone Phosphorylations by Okadaic AcidJournal of Biological Chemistry, 1996
- A C. elegans mutant that lives twice as long as wild typeNature, 1993
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzymeCell, 1993