SYSTEMIC ABSORPTION OF METRONIDAZOLE BY THE VAGINAL ROUTE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 65  (6) , 781-784
Abstract
A study was designed to compare the systemic absorption of metronidazole by the oral and vaginal routes. Nine subjects received single 500 mg doses of the oral, vaginal insert and vaginal cream preparations on 3 occasions. Approximately 20% bioavailability was demonstrated from both vaginal forms. Mean peak plasma concentrations were 15.56 .mu.g/ml for the oral form, 1.86 .mu.g/ml for the cream and 1.89 .mu.g/ml for the insert. The mean times to peak concentration were 1.23 h for the oral dose and 11.11 h and 20.11 h for the cream and insert, respectively. Apparently, some vaginal absorption occurs from both the cream and insert preparations of metronidazole.