Microbiological aspects ofHelicobacter pylori (Campylobacter pylori)

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Abstract
The human gastric pathogenCampylobacter pylori has recently been reclassified asHelicobacter pylori, and a related spiral bacterium found in the stomach of ferrets has been designatedHelicobacter mustelae. The general microbiological features ofHelicobacter pylori are delineated here, with details of phenotypic differences betweenHelicobacter pylori andHelicobacter mustelae; comparisons are made withWolinella succinogenes andCampylobacter jejuni. TheHelicobacter organisms possess an external glycocalyx which can be visualised by electron microscopy, and which may be involved in bacterial adherence. The finding of soluble and cell-associated haemagglutinins ofHelicobacter pylori is reported. Detection ofHelicobacter pylori in clinical specimens, susceptibility of the organism to antibacterial agents, and other aspects of practical and clinical significance are briefly reviewed.