THE INTERACTION OF TRAZODONE WITH RAT BRAIN MUSCARINIC CHOLINOCEPTORS
Open Access
- 1 February 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 71 (2) , 359-361
- https://doi.org/10.1111/j.1476-5381.1980.tb10947.x
Abstract
The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the muscarinic acetylcholine binding site in comparison to the tricyclic antidepressants.Keywords
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