Antidepressants and the Muscarinic Acetylcholine Receptor
- 1 February 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 34 (2) , 236-239
- https://doi.org/10.1001/archpsyc.1977.01770140126014
Abstract
• Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.Keywords
This publication has 12 references indexed in Scilit:
- Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar PatientsArchives of General Psychiatry, 1975
- THE PROPERTIES OF MUSCARINIC RECEPTORS IN MAMMALIAN CEREBRAL CORTEXBritish Journal of Pharmacology, 1974
- Muscarinic Cholinergic Binding in Rat BrainProceedings of the National Academy of Sciences, 1974
- Anti-muscarinic properties of neuroleptics and drug-induced ParkinsonismNature, 1974
- Meprobamate- Benactyzine (Deprol) and Placebo in Two Depressed Outpatient PopulationsPsychosomatics, 1969
- Amitriptyline in childhood enuresisClinical Pharmacology & Therapeutics, 1966
- A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINEBritish Journal of Pharmacology and Chemotherapy, 1964
- Complications from psychotherapeutic drugs‐1964Clinical Pharmacology & Therapeutics, 1964
- DIFFERENT POPULATIONS, DIFFERENT DRUG RESPONSES A COMPARATIVE STUDY OF TWO ANTI-DEPRESSANTS, EACH USED IN TWO DIFFERENT PATIENT GROUPSThe Lancet Healthy Longevity, 1964
- Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activationPsychopharmacology, 1963