Purification of a pituitary polypeptide that stimulates the replication of adipocyte precursors in culture
- 21 March 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 153 (2) , 395-398
- https://doi.org/10.1016/0014-5793(83)80651-6
Abstract
A bovine anterior pituitary polypeptide that stimulates the replication of rat and human adipocyte precursors has been purified. It M r is 44 000–53 000 and its isoelectric point is 9.8–10.3. While pituitary basic fibroblast growth factor is equally mitogenic on adipocyte precursors and skin fibroblasts, the polypeptide described here is selectively more active on the precursors. We postulate that this adipocyte growth factor plays a physiological role by modulating the number of adipocyte precursors.Keywords
This publication has 12 references indexed in Scilit:
- Purification and partial characterization of an acidic fibroblast growth factor from bovine pituitary.Journal of Biological Chemistry, 1982
- Exaggerated replication in culture of adipocyte precursors from massively obese personsMetabolism, 1981
- Preparation and characterization of a novel group of pituitary-derived peptides stimulatory for DNA synthesis in fibroblastsBiochimica et Biophysica Acta (BBA) - Protein Structure, 1980
- Brain fibroblast growth factor: nonidentity with myelin basic protein fragments.Journal of Biological Chemistry, 1980
- Complete differentiation of adipocyte precursorsCell and tissue research, 1978
- Promotion of human adipocyte precursor replication by 17beta-estradiol in culture.Journal of Clinical Investigation, 1978
- Cytological and enzymological characterization of adult human adipocyte precursors in culture.Journal of Clinical Investigation, 1976
- Purification of a fibroblast growth factor from bovine pituitary.Journal of Biological Chemistry, 1975
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951