LIVER BLOOD-FLOW MEASUREMENTS IN PORTACAVALLY TRANSPOSED RAT BEFORE AND AFTER PARTIAL-HEPATECTOMY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (2) , 111-115
Abstract
The hemodynamic changes following partial hepatectomy (PH) in the portacavally transposed rat were studied using an 85Kr clearance technique. Liver blood flow measurements (LBF) were made before and after portacaval transposition (PCT) and PH was performed either immediately or at 3 wk after transposition and further blood flow measurements were made. No change in LBF was noted after PCT compared with preoperative values. Following PH in the portacavally transposed animals there was no marked increase in LBF. The liver atrophy consequent on portal diversion is due to deviation of factors in portal blood and not to a decrease in absolute LBF. Regenerative hyperplasia occurs in the absence of the post-hepatectomy rise in LBF seen in normal animals.