Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation
Open Access
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 20 (22) , 5907-5910
- https://doi.org/10.1093/nar/20.22.5907
Abstract
Copy-DNA clones covering the complete coding sequence of human Elongation Factor-17 mRNA have been isolated and characterized. The expression of Elongation Factor-1 in a variety of cell lines and a number of tissues shows a large increase in Elongation Factor-1γ mRNA going from tissue to cultured cells (20-fold). Messenger-RNA levels for Elongation Factor-17α, -1β and -Iγ increase in parallel suggesting coordinate regulation of the expression of these genes. Oncogenic transformation in vitro does not strongly affect Elongation Factor-1 mRNA levels.Keywords
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