Immunologic Unresponsiveness

Abstract
Two lymphoid cell populations, one from the bone marrow, the other from the thymus, are involved in the immune response to a specific antigen. If either is rendered unresponsive, the individual will be tolerant of that antigen. The significance of this concept for our understanding of autoimmune diseases, for enhancing the ability to transplant organs, and for the management of cancers is evaluated.

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