Phenothiazine phototoxicity: an experimental study on chlorpromazine and related tricyclic drugs
Open Access
- 1 July 1977
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Dermato-Venereologica
- Vol. 57 (4) , 325-329
- https://doi.org/10.2340/0001555557325329
Abstract
A large number of phenothiazines and chemically related tricyclic drugs have been studied with respect to their phototoxic potency. Two methods were used, an in vivo technique based on the inflammatory response of the mouse tail after systemic administration of the drug plus UVA irradiation, and an in vitro method based on growth inhibition of Candida albicans. Of 27 commercial tricyclic drugs tested in vivo, the most potent were chlorpromazine and two other chlorinated compounds, prochlorperazine and perphenazine. Tricyclic drugs lacking nitrogen, sulphur, or both in their ring system showed no activity. All compounds phototoxic in the mouse were so in the yeast test as well. Here, however, the thioxanthenes (lacking nitrogen) were also highly active.This publication has 1 reference indexed in Scilit:
- Phototoxic reaction to chlorpromazine as studied with the quantitative mouse tail techniqueActa Dermato-Venereologica, 1975