Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart
- 26 March 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 283 (5410) , 2080-2082
- https://doi.org/10.1126/science.283.5410.2080
Abstract
Transforming growth factor–β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.Keywords
This publication has 28 references indexed in Scilit:
- Identification of a complex congenital heart defect susceptibility locus by using DNA pooling and shared segment analysisHuman Molecular Genetics, 1997
- Assignment of Human Transforming Growth Factor-β Type I and Type III Receptor Genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, RespectivelyGenomics, 1995
- Mechanism of activation of the TGF-β receptorNature, 1994
- Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sitesThe Journal of cell biology, 1994
- A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene ExpressionScience, 1994
- Cloning and developmental expression of the chick type II and type III TGFβ receptorsDevelopmental Dynamics, 1994
- Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 1992
- Experimental observation of scarred eigenfunctions of chaotic microwave cavitiesPhysical Review Letters, 1991
- Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor βDevelopmental Biology, 1989
- Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissueDevelopmental Biology, 1983