Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.
Open Access
- 1 November 1983
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 158 (5) , 1745-1750
- https://doi.org/10.1084/jem.158.5.1745
Abstract
In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.Keywords
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