Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.
Open Access
- 1 December 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 152 (6) , 1817-1822
- https://doi.org/10.1084/jem.152.6.1817
Abstract
Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.Keywords
This publication has 15 references indexed in Scilit:
- Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro.The Journal of Experimental Medicine, 1979
- Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.Proceedings of the National Academy of Sciences, 1978
- Determinant Selection and Macrophage Function in Genetic Control of the Immune ResponseImmunological Reviews, 1978
- ADHERENT CELL-FUNCTION IN MURINE T-LYMPHOCYTE ANTIGEN RECOGNITION .1. MACROPHAGE-DEPENDENT T-CELL PROLIFERATION ASSAY IN MOUSE1978
- PURIFICATION OF HUMAN MONOCYTES ON MICROEXUDATE-COATED SURFACES1978
- CELLULAR AND GENETIC-CONTROL OF ANTIBODY-RESPONSES INVITRO .4. EXPRESSION OF IA ANTIGENS ON ACCESSORY CELLS REQUIRED FOR RESPONSES TO SOLUBLE-ANTIGENS INCLUDING A RESPONSE UNDER IR GENE CONTROL1978
- Separation of mouse spleen cells by passage through columns of sephadex G-10Journal of Immunological Methods, 1974
- INDUCTION OF T LYMPHOCYTES FROM PRECURSOR CELLS IN VITRO BY A PRODUCT OF THE THYMUSThe Journal of Experimental Medicine, 1973
- IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICEThe Journal of Experimental Medicine, 1973
- ANTIGENS IN IMMUNITY .8. LOCALIZATION OF 125I-LABELLED ANTIGENS IN SECONDARY RESPONSE1965