MODULATORY EFFECT OF SYMPATHETIC NERVOUS-SYSTEM ON NEUROBLASTOMA TUMOR-GROWTH

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (5) , 1374-1375
Abstract
Growth of C-1300 neuroblastoma was suppressed in mice chemically sympathectomized at birth with 6-hydroxydopamine. Growth of A-10 adenocarcinoma was also somewhat reduced. In newborn mice pretreated with nerve growth factor to induce sympathetic nervous system neuronal hypertrophy, neuronal maturation and peripheral hyperinnervation, the growth of neuroblastoma was augmented.

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