Autoimmune Hemolytic Anemia Associated with IgG Auto Anti‐N

Abstract
A second case of autoimmune hemolytic anemia mediated by an IgG auto Anti‐N is described. The patient's red blood cells were sensitized with both IgG and complement. The serum antibody was not inactivated by 2‐mercaptoethanol treatment, and reacted by indirect antiglobulin test at 37 C with monospecific anti‐IgG. The IgG antibody eluted from the red blood cells and in the serum showed anti‐N specificity. The patient was thought to have systemic lupus erythematosus. Following steroid therapy, the hemolytic anemia resolved with disappearance of the anti‐N.