An efficient algorithm to compute the posterior genotypic distribution for every member of a pedigree without loops

1 October 1993

journal article
Published by Springer Nature in Theoretical and Applied Genetics

Vol. 87 (1) , 89-93
https://doi.org/10.1007/bf00223750

Abstract

This paper describes a non-iterative, recursive method to compute the likelihood for a pedigree without loops, and hence an efficient way to compute genotype probabilities for every member of the pedigree. The method can be used with multiple mates and large sibships. Scaling is used in calculations to avoid numerical problems in working with large pedigrees.

Keywords

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