Tetracycline in the treatment of rheumatoid arthritis. A double blind controlled study

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Abstract
Mycoplasmas have been implicated as etiologic agents in rheumatoid arthritis and it has been suggested that tetracycline, which inhibits the growth of these organisms, is beneficial in the treatment of this disease. To test this hypothesis, 27 patients with classical or definite rheumatoid arthritis were selected from three university hospital arthritis clinics and assigned at random to treatment for one year with either tetracycline 250 mg/day or a placebo. The results demonstrated no significant benefit from tetracycline therapy.