COMPARISON OF NITROPRUSSIDE AND HYDRALAZINE IN HYPERTENSIVE PREGNANT EWES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (5) , 598-602
Abstract
During phenylephrine-induced hypertension in 6 near-term pregnant ewes, nitroprusside rapidly lowered the blood pressure to control values with no accompanying change in uterine blood pressure to control values. This change was accompanied by a statistically significant (15%) increase in uterine blood flow. Hydralazine also had a more pronounced effect than nitroprusside on cardiac output (.uparw.), heart rate ((.uparw.) and total peripheral resistance (.dwnarw.). There were no significant acid-base changes in mother or fetus throughout the study.

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